P-132 Does the automated blastocyst assessment system, iDAScore®, provide valuable data for predicting the results of preimplantation genetic testing for aneuploidy (PGT-A)?

Abstract Study question What iDAScore® could indicate the presence of euploidy in PGT-A? Is it a valid predictor result Summary answer PGT-A results with an 8.3 or higher can euploidy. However, patient age and trophectoderm (TE) grade be effective predictors as well. is known already was approved general test Japan 2022. Currently, only patients who meet criteria Society Obstetrics Gynecology undergo test. It expected that will improve live birth rate reduce miscarriage rate. The uses artificial intelligence deep learning to score blastocysts. anticipated more objective than morphological evaluation, which varies among individuals. Unlike PGT-A, assess embryos without cellular invasion. few reports have investigated association between results. design, size, duration study performed retrospectively on 3,781 cycles vitro fertilization (IVF) conducted at our clinic August 2020 October Of total 5,684 derived from conventional IVF intracytoplasmic sperm injection were cultured time lapse incubator, 293 blastocysts used study. Participants/materials, setting, methods On basis their results, divided into aneuploidy groups. mean each group, insemination, median evaluated. area under curve (AUC) cut-off value calculated A logistic regression analysis predictive parameters including iDAScore®, also performed. Main role chance Patients’ ages groups 38.5 41.5 years, respectively. This significantly group (P<0.001). There no significant difference stage maturity oocyte retrieval (P = 0.302). Similarly, differences associated method insemination 0.961). for 8.7; 7.8. AUC, receiver operating characteristic curves, 0.685 (95% CI [0.617−0.754]). 8.3. age, maturity, method, timing blastocyst freezing, diameter before inner cell mass, TE Gardner classification, indicated (age: P<0.001, odds ratio [95%CI]: 1.320 [1.19-1.45]; 2: P 0.03, 2.480 [1.11-5.57]; 3: 0.02, 3.740 [1.27-11.00]), while iDAScore®. Limitations, reasons caution likely depend freezing. Furthermore, utilised this fulfilled freezing criteria; reaches size least 150-160 µm Day 5,6, 7 frozen. Wider implications findings An above result. was. Therefore, difficult predict itself. Trial registration number Not applicable